The mechanism of mitochondrial extrusion from reticulocytes in the spleen from patients with erythrocyte pyruvate kinase (PK) deficiency.

S 753 in the majority of the animals. The following four consecutive phases of changes in organs and blood could be distinguished: (I) a nonspecific phase with accumulation of leukocytes in the lymph nodes, accompanied by increase in the numbers of polymorphonuclear leukocytes in the peripheral blood: (2) preliminary phase with stimulation of the granulocytic system in the spleen and lymph nodes, focal atrophy of the thymic cortex, and accumulation of polymorphonuclear leukocytes in the thymus, usually accompanied by granulocytopenia in the peripheral blood; (3) a borderline phase with young cell forms of the granulocytic system in the spleen and lymph nodes, and their increase in the bone marrow. The number of granulocytes in the peripheral blood usually increased and a few pathologic forms appeared: (4) a leukemic phase, with leukemic infiltration of the organs and typical leukemic peripheral blood picture. -M.K. Morphologic Lesions in the Organs of Mice in the Course of Leukemogenesis Under the In. fluence of Graffi Virus. II. Mice Infected with Cell-free Filtrate of the Organs of Mice With Lymphatic Leukemia. A. Niezabitowski. Depart. ment of Anatomopathology, School of Medicine, KrakOw, Poland. Patol Pol 24:505-525, 1973 Mice of the inbred XVII BIm strain, I 3 days after birth, were infected with filtrate of the organs of animals with lymphatic leukemia induced by the Graffi virus. Groups of mice were killed at 10 day intervals, and the peripheral blood picture and morphologic lesions in the internal organs were evaluated. Lymphatic or lymphoreticular leukemia developed in the investigated group of mice. The morphologic changes in the thymus were correlated with the changes in the spleen and lymph nodes. Four phases of leukemogenesis were distinguished: (I) a nonspecific phase with accumulation of leukocytes in the lymph nodes. accompanied by increased numbers of polymorphonuclears in the peripheral blood: (2) a preliminary phase, with atrophy of the thymic cortex and enlargement of splenic follicles and granulocytopenia in the peripheral blood: (3) a borderline phase, with proliferation of reticuloendothelial cells in the thymus and atrophy of lymphoid structure in the lymph nodes, leading to formation of granulomatous foci, accompanied by an increase in the numbers of granulocytes and a decrease in lymphoidal cells in the peripheral blood. (4) pathologic forms of lymphoid cells in the peripheral blood were first observed in the leukemic phase, accompanied by leukemic hyperplasia in the